Here we present and develop the hypothesis that the derepression of endogenous retrotransposable elements (RTEs) – “genomic parasites” – is an important and hitherto under‐unexplored molecular aging process that can potentially occur in most tissues. We further envision that the activation and continued presence of retrotransposition contribute to age‐associated tissue degeneration and pathology. Chromatin is a complex and dynamic structure that needs to be maintained in a functional state throughout our lifetime. Studies of diverse species have revealed that chromatin undergoes (...) extensive rearrangements during aging. Cellular senescence, an important component of mammalian aging, has recently been associated with decreased heterochromatinization of normally silenced regions of the genome. These changes lead to the expression of RTEs, culminating in their transposition. RTEs are common in all kingdoms of life, and comprise close to 50% of mammalian genomes. They are tightly controlled, as their activity is highly destabilizing and mutagenic to their resident genomes. (shrink)

ABSTRACT Psychological or political criticism of the parent‐child relation presupposes a normative account of that relation. Such an account is here provided. The normative account can shed most light when the parent‐child relation is presented recognizably, not in Utopian disguise. The purposes of reasonable people partly depend on their interpretations of those of their parents. This is so whether such people accept or reject any particular parental purposes. The filial art sticks to the project of working out the enacted interpretation—until (...) it gets it approximately right. There is a corresponding parental art, neither compensatory nor sacrificial. (shrink)

A philosophical study of the ethics of good and evil. Ch. 6 (pp. 163-207), "Banality and Originality, " takes issue with Hannah Arendt's thesis of the banality of evil. Contends that no legally sane Nazi was free of evil. The individual has free choice in regard to doing good and evil, and is responsible for his evil acts. Takes issue, also, with Raul Hilberg's view that the Jews did not resist the Nazi terror, and asks "What is the right way (...) to act during one's Holocaust?" Ch. 7 (pp. 209-220), "Thinking Like a Nazi, " analyzes the Nazi mentality, again showing that the individual cannot claim to have been led astray or to have been controlled by his subconscious - at every stage he was a free agent deliberately choosing evil. (shrink)

This book provides actionable steps for educators to commit to inclusion of diversity immediately, working toward culturally responsive teaching.

In these skeptical and disillusioned times, there are still groups of people scattered throughout the world who are trying to live out utopian dreams. These communities challenge the inevitability and morality of dominant political and economic models. By putting utopian religious ethics into practice, they attest to the real possibility of social alternatives. In Seeds of the Kingdom, Anna L. Peterson reflects on the experiences of two very different communities, one inhabited by impoverished former refugees in the mountains of (...) El Salvador and the other by Amish farmers in the Midwestern U.S. What makes these groups stand out among advocates of environmental protection, political justice, and sustainable development is their religious orientation. They aim, without apology, to embody the reign of God on earth. The Salvadoran community is grounded in Roman Catholic social thought, while the Amish adhere to Anabaptist tradition. Peterson offers a detailed portrait of these communities' history, social organization, religious life, environmental values, and agricultural practices. She discovers both practical and ideological commonalities in these two comparatively successful and sustainable communities, including a strong collective identity, deep attachment to local landscapes, a desire to preserve non-human as well as human lives, and, perhaps unexpectedly, a utopian horizon that provides both goals and the hope of reaching them. By examining the process by which people struggle to live according to a transcendent value system, she sheds light on both the actual and the potential place of religion in public life. Peterson argues that the Amish and Salvadoran communities, geographically and culturally removed from the industrialized West, have relevance for the political and environmental problems of the developed world. These communities have succeeded in the face of significant internal and external challenges, offering important practical and theoretical lessons on how to achieve ecological sustainability and social justice in the wider world. (shrink)

Control stimuli are key for understanding the extent to which face processing relies on holistic processing, and affective evaluation versus the encoding of low-level image properties. Luminance polarity reversal combined with face inversion is a popular tool for severely disrupting the recognition of face controls. However, recent findings demonstrate visibility-recognition trade-offs for LP-reversed faces, where these face controls sometimes appear more salient despite being harder to recognize. The present report brings together findings from image analysis, simple stimuli, and behavioral data (...) for facial recognition and visibility, in an attempt to disentangle instances where LP-reversed control faces are associated with a performance bias in terms of their perceived salience. These findings have important implications for studies of subjective face appearance, and highlight that future research must be aware of behavioral artifacts due to the possibility of trade-off effects. (shrink)

Conversions: A Philosophic Memoir belongs to the tradition of Augustine and Rousseau: the "confession" of a life that is a quest for truth. It is in large part the story of two major episodes from Abigail Rosenthal's early adulthood, bought putting personal identity dramatically at risk. As a young Fulbright scholar in Paris, Rosenthal met and entered reluctantly into a love affair with a young Greek communist philosopher who believed (along with many Parisian intellectuals of that era) that force (...) and deception were justified by a utopian vision of world history. In the inevitable collision of values—between Jew and Greek, liberal and revolutionary, theist and atheist, woman and man in unequal truggle—they separated. Suffering in the aftermath, she at last turned for help to a young African American woman graduate student whom she met in London. This woman's Gnostic Christian rejection of personal and cultural history eventually left Rosenthal without defense against her new mentor's remarkable use of charisma, ridicule, and moralistic reproach to usurp the author's life story. These stratagems of mind control reached a climactic phase in Portugal, where the two went—Rosenthal to paint the other woman to write—in what would turn out to be the terrifying reverse of a summer idyll. With the U.S. State Department, the Portuguese Policía Internacional devised an extraordinary rescue. This arresting narrative, which deals with relations between blacks and whites, Christians and Jews, and men and women, delivers its own philosophic theory of the individual in history. Author note: Abigail L. Rosenthal is Professor of Philosophy at Brooklyn College of The City University of New York and the author of A Good Look at Evil (Temple). (shrink)

More than twenty years ago the late Bernard Williams published a paper under the oxymoronic title of ‘Moral Luck’, which claimed that chance shapes moral standing, and that moral standing, like social or professional standing, has its winners and losers, successes and failures. Williams’ final book, Truth and Truthfulness: An Essay in Genealogy, offered as a ‘fiction’ a sociobiological genealogy of moral standing, and worked to free some of the virtues associated with it—such as integrity, Accuracy, and Sincerity—from the taint (...) of these presumed primitive origins. Whatever the proceeds of this exercise in saving reductionism from itself, it seemed that ‘moral luck’—the earlier category—had come through it essentially undamaged. (shrink)

It was news verging on sensational when A. J. Ayer came back from four minutes of heart death with a report of what he saw. Especially since the philosopher, who publicized his near-death experience [NDE] in 1988, in the Telegraph and the Spectator, was known for his lifelong rejection of religion and the supernatural. But, as will be seen, Ayer's beliefs on that head were substantially unchanged, if more ambivalently expressed, and the interest of his NDE lies elsewhere— in what (...) it reveals about his philosophy. (shrink)

Arendt claims that evil is banal and its perpetrators merely shallow. Deliberate evil she takes to be extremely rare. However, nonrare examples of deliberate evil, whose aim is to spoil one's story, abound in everyday life. Arendt also makes forgiveness personal, not requiring repentance. This prompts a consideration of certain personal relations among philosophers. Heidegger's relation to Husserl shows a betrayal of teacher by student. His seductive and philosophic power over Arendt, a betrayal of student by teacher, should not be (...) dismissed in terms of reductive Freudian notions. Faced with a real feminine predicament, Arendt made the wrong choices: in her exoneration of Heidegger, her report on the Eichmann trial, and her exculpatory doctrine of evil. (shrink)

Taking exception to Gilbert Ryle's influentially ironical remark about introspection, that it would be like peering into a 'windowless chamber illuminated by a very peculiar sort of light, and one to which only he [the one attempting the introspecting] has access', this essay claims that introspective awareness of one's actions and motivations in their chronological sequence is not empty but highly informative, not trivial but inseparable from any significant life, and not hopeless but entirely feasible. It is argued that informative (...) and significant introspective awareness is a practice which ought to be as unbroken as possible, not fetched into consciousness or dismissed therefrom at whim in discrete quanta. Philosophers of mind for whom self-awareness is a surd will, however, naturally be inclined to attend to it reluctantly, thus without the requisite persistence, and without understanding it to be a skilled practice. This essay offers a preliminary map of the territory of introspection, which it defines under the heading of 'inner space and inner time.' It shows what sorts of conceptual clarifications are to be gained by the introspective practice it recommends, what responsibilities grasped, and what missteps avoided. (shrink)

Theory of Mind (ToM) is the cognitive achievement that enables us to report our propositional attitudes, to attribute such attitudes to others, and to use such postulated or observed mental states in the prediction and explanation of behavior. Most normally developing children acquire ToM between the ages of 3 and 5 years, but serious delays beyond this chronological and mental age have been observed in children with autism, as well as in those with severe sensory impairments. We examine data from (...) studies of ToM in normally developing children and those with deafness, blindness, autism and Williams syndrome, as well as data from lower primates, in a search for answers to key theoretical questions concerning the origins, nature and representation of knowledge about the mind. In answer to these, we offer a framework according to which ToM is jointly dependent upon language and social experience, and is produced by a conjunction of language acquisition with children's growing social understanding, acquired through conversation and interaction with others. We argue that adequate language and adequate social skills are jointly causally sufficient, and individually causally necessary, for producing ToM. Thus our account supports a social developmental theory of the genesis of human cognition, inspired by the work of Sellars and Vygotsky. How are we to decide whether to take reason to be an essentially private thing that can, however, turn on a public display when it chooses to do so, or, like conversing, to be an essentially social skill, which can, however, be retained a while through periods of solitary confinement? (Annette Baier, The Commons of the Mind, p. 5). The squirrel does not infer by induction that it is going to need stores next winter as well (Wittgenstein, On Certainty§ 287). The problem of thought and language thus extends beyond the limits of natural science and becomes the focal problem of historical human psychology, i.e. of social psychology. Consequently, it must be posed in a different way (Vygotsky, Thought and Language, p. 51). From the very first days of the child's development his activities acquire a meaning of their own in a system of social behaviour and, being directed towards a definite purpose, are refracted through the prism of the child's environment. The path from object to child and from child to object passes through another person. This complex human structure is the product of a developmental process deeply rooted in the links between individual and social history (Vygotsky, Mind in Society, p. 30). (shrink)

In his seminal essay “Two Concepts of Liberty,” Isaiah Berlin categorized freedom into positive or negative liberty: “freedom to” or “freedom from.” He provided a powerful critique against the metaphysical nature of positive liberty, arguing that it is oppressive, in contrast to the conception of negative freedom, defined as lack of interference. Meanwhile, conversations around the concept of freedom in Daoist philosophy often hover around categorizing it as either positive liberty in its spiritual form—what Berlin calls the “retreat to the (...) inner citadel”—or a type of negative liberty, being free from society’s interference. In this work, I argue that it may instead be more fruitful to explore the Chinese commentarial tradition for two reasons: (1) the problem of Berlin’s liberalist framework is problematic due to its inherently Anglo-European context, and concurrently, (2) there have been rich discussions of the sociopolitical aspects of the _Zhuangzi_ 莊子, especially by its leading Chinese commentator G uo Xiang 郭象, which have not been accounted for. Drawing from G uo Xiang, I render a reading of the concept of “free and easy wandering” (_xiaoyao_ 逍遙) in the _Zhuangzi_ as it directly relates to self-realization (_zide_ 自得) and having no heart-mind (_wuxin_ 無心), which makes for a more holistic understanding of freedom as self-determination. In particular, I argue that freedom in the philosophy of the _Zhuangzi_ can be more aptly understood as “freedom in,” which is more viable and just than both “freedom to” and “freedom from.”. (shrink)

Typically, the quantification and management of population as a reason of state is associated with modernity. As scholars, we tend to take this for granted, especially in our post-Foucauldian theor...

Typically, the quantification and management of population as a reason of state is associated with modernity. As scholars, we tend to take this for granted, especially in our post-Foucauldian theor...

Themes of Christian martyrdom were central to popular political mobilization in El Salvador, as in much of Latin America, during the 1970s and 1980s. The story of Christ's sacrifice provided a powerful narrative for explaining injustice and political violence, a frame for interpretation as well as action during the twelve-year Salvadoran civil war, which ended in 1992 by a negotiated settlement. In the first part of this article we trace the politics of martyrdom and sacrifice through the war. The final (...) sections of the article examine the place of narratives of martyrdom and sacrifice in post-civil war El Salvador. While most Salvadorans today continue to experience high levels of inequality, poverty, and violence, the narratives of martyrdom and sacrifice that animated the revolutionary movements and liberation theology of the 1980s have lost much of their resonance. We suggest that the dispersion of both the perceived sources of, and the imagined solutions to, injustice contribute to the diminution in the importance of Christian narratives of martyrdom and sacrifice in El Salvador today. (shrink)

In this article, we focus on two issues, namely, the nature and onset of very early personal memories, especially for traumatic events, and the role of stress in long-term retention. We begin by outlining a theory of early autobiographical memory, one whose unfolding is coincident with emergence of the cognitive self. It is argued that it is not until this self emerges that personal memories will remain viable over extended periods of time. We illustrate this with 25 cases of young (...) children′s long-term retention of early traumatic events involving emergency room treatment. On the basis of both qualitative and quantitative analyses, we conclude that very young children retain limited memories for events which they commonly express behaviorally, coherent autobiographical memories are not constructed until the child develops a cognitive sense of self , autobiographical memories for traumatic events are essentially no different from those for nontraumatic events, stress is only related to long-term retention inasmuch as it is one variable that serves to make an event unique, and like nontraumatic events, traumatic memories lose peripheral details during the retention interval and retain the central components of the event. These results are discussed both in terms of their implications for theories of early autobiographical memory as well as the ways in which we might differentiate implanted memories and authentic memories for traumatic events. (shrink)

This excellent anthology in the philosophy of religion examines the basic classical and a host of contemporary issues in thirteen thematic sections. Assuming little or no familiarity with the religious concepts it addresses, it provides a well-balanced and accessible approach to the field. The articles cover the standard topics in the field, including religious experience, theistic arguments, the problem of evil, and miracles, as well as topics that have gained the attention of philosophers of religion in the last fifteen years, (...) such as reformed epistemology, the philosophical analysis of theological doctrine, and the kalam theological argument. The collection also includes topics often requested by instructors but seldom covered in competing texts, such as religion and science, religious pluralism, process theism, and religious ethics, offering greater flexibility in choosing exact topics for use in courses. The format of the book makes it an ideal teaching text, as each section begins with a brief introduction to the central topic or issue treated by the readings which follow. Each reading is preceded by a one paragraph summary, and a bibliography of suggested readings follow each section. Philosophy of Religion functions well as a stand-alone textbook for courses in the philosophy of religion, and is readily compatible for use as a primary source reader in conjunction with a secondary text. It is an ideal companion to Reason and Religious Belief, 2e (OUP, 1997). (shrink)

I would try to reduce the anxiety to realizing that seemingly the same proposition is really different when it is false by pointing out that the contents of two of our beliefs can be different when we think they are the same as well as being the same when we think they are different. That is, belief contents are not infallibly known or knowable in conscious reflective awareness of beliefs. Trying or wanting to accurately perceive what you are thinking does (...) not guarantee success. We can be wrong even about what we believe our beliefs are we don't and maybe can't realize that two beliefs are contradictory). (shrink)

I would try to reduce the anxiety to realizing that seemingly the same proposition is really different when it is false by pointing out that the contents of two of our beliefs can be different when we think they are the same as well as being the same when we think they are different. That is, belief contents are not infallibly known or knowable in conscious reflective awareness of beliefs. Trying or wanting to accurately perceive what you are thinking does (...) not guarantee success. We can be wrong even about what we believe our beliefs are we don't and maybe can't realize that two beliefs are contradictory). (shrink)

Environmental ethics has been dominated by an idealist logic that limits its positive impact on the natural world about which environmental philosophers care deeply. Environmental ethicists need to alter the ways we think and talk about what we value and the relations among ideas, values, and actions. Drawing on the sociology of religion and Marxian philosophy among other sources, a new approach may increase our understanding of how ideas are lived out and how we might increase the impact of our (...) ideas about the value of nature. (shrink)

Legal, medical, and public health professionals have been complicit in creating and maintaining systems that drive health inequities. To ameliorate this, current and future leaders in law, medicine, and public health must learn about racism and its impact along the life course trajectory and how to engage in antiracist practice and health equity work.

Theory of Mind is the cognitive achievement that enables us to report our propositional attitudes, to attribute such attitudes to others, and to use such postulated or observed mental states in the prediction and explanation of behavior. Most normally developing children acquire ToM between the ages of 3 and 5 years, but serious delays beyond this chronological and mental age have been observed in children with autism, as well as in those with severe sensory impairments. We examine data from studies (...) of ToM in normally developing children and those with deafness, blindness, autism and Williams syndrome, as well as data from lower primates, in a search for answers to key theoretical questions concerning the origins, nature and representation of knowledge about the mind. In answer to these, we offer a framework according to which ToM is jointly dependent upon language and social experience, and is produced by a conjunction of language acquisition with children's growing social understanding, acquired through conversation and interaction with others. We argue that adequate language and adequate social skills are jointly causally sufficient, and individually causally necessary, for producing ToM. Thus our account supports a social developmental theory of the genesis of human cognition, inspired by the work of Sellars and Vygotsky.How are we to decide whether to take reason to be an essentially private thing that can, however, turn on a public display when it chooses to do so, or, like conversing, to be an essentially social skill, which can, however, be retained a while through periods of solitary confinement? .The squirrel does not infer by induction that it is going to need stores next winter as well .The problem of thought and language thus extends beyond the limits of natural science and becomes the focal problem of historical human psychology, i.e. of social psychology. Consequently, it must be posed in a different way .From the very first days of the child's development his activities acquire a meaning of their own in a system of social behaviour and, being directed towards a definite purpose, are refracted through the prism of the child's environment. The path from object to child and from child to object passes through another person. This complex human structure is the product of a developmental process deeply rooted in the links between individual and social history. (shrink)

ABSTRACT:Psychedelic substances have great promise for the treatment of many conditions, and they are the subject of intensive research. As with other medical treatments, both research and clinical use of psychedelics depend on our ability to ensure informed consent by patients and research participants. However, some have argued that informed consent for psychedelic use may be impossible, because psychedelic experiences can be transformative in the sense articulated by L. A. Paul (2014). For Paul, transformative experiences involve either the acquisition of (...) knowledge that cannot be obtained in any other way or changes in the self. Either of these characteristics may appear to undermine informed consent. This article argues, however, that there is limited evidence that psychedelic experiences are transformative in Paul's sense, and that they may not differ in their transformative features from other common medical experiences for which informed consent is clearly possible. Further, even if psychedelic experiences can be transformative, informed consent is still possible. Because psychedelic experiences are importantly different in several respects from other medical experiences, this article closes with recommendations for how these differences should be reflected in informed consent processes. (shrink)

Convolutional neural networks (CNNs) are increasingly widely used in psychology and neuroscience to predict how human minds and brains respond to visual images. Typically, CNNs represent these images using thousands of features that are learned through extensive training on image datasets. This raises a question: How many of these features are really needed to model human behavior? Here, we attempt to estimate the number of dimensions in CNN representations that are required to capture human psychological representations in two ways: (1) (...) directly, using human similarity judgments and (2) indirectly, in the context of categorization. In both cases, we find that low-dimensional projections of CNN representations are sufficient to predict human behavior. We show that these low-dimensional representations can be easily interpreted, providing further insight into how people represent visual information. A series of control studies indicate that these findings are not due to the size of the dataset we used and may be due to a high level of redundancy in the features appearing in CNN representations. (shrink)

Decades of psychological research have been aimed at modeling how people learn features and categories. The empirical validation of these theories is often based on artificial stimuli with simple representations. Recently, deep neural networks have reached or surpassed human accuracy on tasks such as identifying objects in natural images. These networks learn representations of real‐world stimuli that can potentially be leveraged to capture psychological representations. We find that state‐of‐the‐art object classification networks provide surprisingly accurate predictions of human similarity judgments for (...) natural images, but they fail to capture some of the structure represented by people. We show that a simple transformation that corrects these discrepancies can be obtained through convex optimization. We use the resulting representations to predict the difficulty of learning novel categories of natural images. Our results extend the scope of psychological experiments and computational modeling by enabling tractable use of large natural stimulus sets. (shrink)

No detailed description available for "Concepts and language".

Consider syllogisms in which fraction (percentage) quantifiers are permitted in addition to universal and particular quantificrs, and then include further quantifiers which are modifications of such fractions (such as "almost ½ the S are P" and "Much more than ½ the S are P"). Could a syllogistic system containing such additional categorical forms be coherent? Thompson's attempt (1986) to give rules for determining validity of such syllogisms has failed; cf. Carnes & Peterson (forthcoming) for proofs of the unsoundness and (...) incompleteness of Thompson's rules. Building on Peterson (1985), the coherence of such a syllogistic can, however, be demonstrated with an algebra which provides its semantics; e.g., "almost ¾ the S arc P'" is represented as " -(3(SP) » SP)". (shrink)